[1]王进,董晓强,朱新国,等.IL-9在结肠癌组织中的表达及其临床意义[J].南方医科大学学报,2018,(08):943.
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IL-9在结肠癌组织中的表达及其临床意义()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2018年08期
页码:
943
栏目:
出版日期:
2018-07-31

文章信息/Info

Title:
Expression of interleukin-9 in colon cancer tissues and its clinical significance
作者:
王进董晓强朱新国赵华毛德利赵鑫
关键词:
IL-9结肠癌免疫组化预后
Keywords:
interleukin-9 colon cancer immunohistochemistry prognosis
摘要:
目的探讨IL-9在结肠癌组织中的表达水平及其临床意义。方法采用免疫组化法和实时荧光定量PCR(qRT-PCR)法分 别检测92例结肠癌组织及相应癌旁正常组织中IL-9的表达情况;统计分析IL-9在结肠癌与癌旁正常组织中的表达差异;分析 IL-9蛋白表达与结肠癌患者的临床病理特征及生存预后之间的关系。结果在癌旁正常组织中IL-9蛋白及mRNA的表达水平 均显著高于结肠癌组织(P<0.001)。IL-9 蛋白表达水平与结肠癌患者的TNM分期、Ducks 分期及淋巴结转移相关(P=0.013, 0.025, 0.004),而与性别、年龄、肿瘤大小、分化程度及肝转移等临床病理特征无明显相关性(P>0.05)。IL-9表达阳性结肠癌患 者的生存时间明显长于阴性表达的患者(P=0.015)。结论IL-9在结肠癌组织中较在癌旁正常组织中低表达;IL-9在结肠癌组 织中的表达与TNM分期、Ducks分期及淋巴结转移呈负相关,与良好预后呈正相关,提示在结肠癌肿瘤微环境中IL-9发挥了重 要的作用。
Abstract:
Objective To investigate the expression of interleukin-9 (IL-9) in colon cancer tissues and its clinical significance. Methods Immunohistochenmistry and qRT-PCR were used to detect the expressions of IL-9 protein and mRNA in 92 colon cancer tissues and paired adjacent normal tissues. The correlation of IL-9 expressions with the clinicopathological features and prognosis of the patients was analyzed. Results IL-9 protein and mRNA expressions were significantly higher in adjacent normal tissues than in the colon cancer tissues (P<0.001). In colon cancer patients, IL-9 expression was significantly correlated with TNM stage (P=0.013), Ducks stage (P=0.025) and lymph node metastasis (P=0.004) but not with gender, age, tumor size, differentiation or hepatic metastasis (P>0.05). The survival time of colon cancer patients with positive IL-9 expression was significantly longer than that of patients negative for IL-9 expression (P=0.015). Conclusions IL-9 expression is lowered in colon cancer tissues compoved with in the adjacent normal tissues. IL-9 expression is negatively correlated with TNM staging, Ducks staging and lymph node metastasis but positively with good prognosis, suggesting its important role in the tumor microenvironment of colon cancer.

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更新日期/Last Update: 1900-01-01