[1]王超民,刘铁坚,宋振华,等.离体灭活多孔骨瓣结合BAM骨诱导人工骨修复大鼠颅骨缺损的效果评价[J].南方医科大学学报,2018,(06):748.
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离体灭活多孔骨瓣结合BAM骨诱导人工骨修复大鼠颅骨缺损的效果评价()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2018年06期
页码:
748
栏目:
出版日期:
2018-06-30

文章信息/Info

Title:
Efficacy of inactivated autologous porous bone flap and BAM bone-induced artificial bone for repairing skull defect in rats
作者:
王超民刘铁坚宋振华郭小瑜魏大年刘承勇
关键词:
BAM骨诱导人工骨灭活自体骨瓣颅骨缺损颅骨修补再生
Keywords:
BAM bone-induced artificial bone inactivated autologous bone flap skull defect cranioplasty regeneration
摘要:
目的研究离体灭活多孔骨瓣结合BAM骨诱导人工骨通过骨诱导成骨修复颅骨骨缺损的作用。方法72只Wistar大鼠颅 骨骨缺损建模后随机分为4组:骨缺损未修复组(CON组)、灭活自体骨瓣支架治疗组(AB组)、BAM骨诱导人工骨材料治疗组 (BAM组)和灭活自体骨瓣支架结合BAM骨诱导人工骨材料治疗组(BAM+AB组)。颅骨骨缺损建模术后1、2、3个月取标本, Micro-CT观察颅骨缺损的愈合情况,组织学观察新生骨形成情况。结果离体灭活多孔骨瓣结合BAM骨诱导人工骨可诱导大 鼠颅骨缺损的血管与纤维组织再生;离体灭活多孔骨瓣结合BAM骨诱导人工骨可诱导大鼠颅骨缺损成骨发生;BAM骨诱导人 工骨在离体灭活多孔骨瓣支撑下可使颅骨缺损更好恢复颅骨外观。结论应用离体灭活自体骨瓣和BAM骨诱导人工骨复合材 料修补颅骨缺损,不仅可以促进颅骨愈合,而且避免了材料脆性过大不能成型的弊端,使颅骨外观恢复原貌,达到颅骨表面局部 解剖重建要求,是颅骨缺损有效可行的方法。
Abstract:
Objective To study the effect of BAM bone grafting combined with inactivated autologous porous bone flap in repairing skull defect in rats. Methods Seventy-two Wistar rats with skull defect were randomly divided into control group, inactivated autologous bone flap group (AB group), BAM bone-induced artificial bone material group (BAM group), and inactivated autologous bone flap with BAM bone-induced artificial bone group (BAM + AB group). The bone healing was evaluated with micro-CT and the new bone formation was assessed with histological staining at 1, 2, and 3 months after modeling. Results Inactivated porous bone flap combined with BAM bone-induced artificial bone effectively induced vascular and fibrous tissue regeneration and osteogenesis in the cranial defects. With the inactivated porous bone flap as the scaffold, BAM bone-induced artificial bone obviously promoted the restoration of the skull appearance in the rats with cranial defects. Conclusion Inactivated autologous bone flap group and BAM bone-induced artificial bone material can promote skull healing and restoration of the original skull appearance, and can be used for reconstruction of the local anatomy of the skull surface.
更新日期/Last Update: 1900-01-01