[1]梁倩,汪新宇,胡豪飞,等.2型糖尿病患者空腹C肽与血尿酸水平的相关性[J].南方医科大学学报,2018,(04):490.
点击复制

2型糖尿病患者空腹C肽与血尿酸水平的相关性()
分享到:

《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2018年04期
页码:
490
栏目:
出版日期:
2018-04-30

文章信息/Info

Title:
Correlation between fasting C-peptide and serum uric acid in patients with type 2 diabetes mellitus
作者:
梁倩汪新宇胡豪飞赖嘉宝姚伟力陈妙玲饶茜
关键词:
2型糖尿病空腹C肽血尿酸
Keywords:
type 2 diabetes mellitus fasting C-peptide serum uric acid
摘要:
目的探讨2型糖尿病(T2DM)患者空腹C肽(F-CP)与血尿酸(SUA)水平之间的关系。方法选取347例住院的T2DM患 者,根据F-CP水平按照四分位法分为4个亚组,依次为C1(<0.74 ng/mL)、C2(0.74~1.21 ng/mL)、C3(1.22~1.87 ng/mL)、C4(> 1.87 ng/mL),比较各亚组患者一般资料及临床指标的差异,并探讨随着F-CP亚组水平的增加,SUA的水平以及高尿酸血症 (HUA)的发病率的变化。按照SUA水平分为升高组(>420 μmol/L)和正常组(≤420 μmol/L),分别比较两组患者一般资料、空 腹C肽以及其他临床指标等的差异,分析两组患者SUA水平与F-CP水平等一系列指标的相关性。采用二元Logistic回归及多 元回归方程分析、分层交互检验分析探讨SUA升高的危险因素。利用ROC曲线分析影响SUA升高的所有独立危险因素,观察 F-CP对SUA的影响程度,寻找相应的cut-off值。结果与正常组SUA相比,SUA升高组患者体质量指数(BMI)、腰臀比、F-CP、 餐后2hC 肽(2hP-CP)、甘油三酯(TG)、同型半胱氨酸(HCY)、血肌酐(SCr)等水平增加(均P<0.05),合并饮酒史比率较高 (44.8% vs 32.6%,P=0.006);而糖化血红蛋白(HbA1c)、高密度脂蛋白(HDL)、估算肾小球滤过率(eGFR)水平偏低(均P< 0.05)。相关性分析结果证明,SUA与F-CP、2hP-CP、BMI、腰臀比、舒张压、TG、HCY、SCr、吸烟史、饮酒史等呈正相关(均P< 0.05),而与性别、年龄、发病年龄、HbA1c、高密度脂蛋白(HDL)、eGFR等呈负相关(均P<0.05)。F-CP四个亚组间存在着明显差 异(P<0.0001),且随着F-CP的增加,SUA水平及高尿酸血症的发病率也随之增加(P<0.05)。Logistic回归及多元线性回归方程 分析表明,F-CP是SUA升高的独立危险因素。性别分层交互检验分析显示,性别不会影响F-CP与SUA的关系。ROC曲线表 明,当F-CP在1.260 ng/mL以上时,T2DM患者出现高尿酸血症几率将明显增加。结论T2DM患者F-CP与SUA之间关系密 切,F-CP可能是预测T2DM患者血尿酸升高的独立危险因素。
Abstract:
Objective To explore the relationship between fasting C-peptide (F-CP) and serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM). Methods A total of 347 hospitalized patients with T2DM were stratified according to F-CP level to analyze the impact of increased F-CP levels on SUA level and the incidence of hyperuricemia (HUA). The patients with an elevated SUA level (>420 μmol/L) and a normal SUA level (≤420 μmol/L) were compared for general data, fasting C-peptide and other clinical indexes. Pearson or Spearman correlation analysis was used to analyze the correlation of SUA level with F-CP levels and other parameters. The risk factors of elevated SUA were analyzed by binary logistic regression, multiple regression analysis and hierarchical interaction analysis. The ROC curve was used to analyze the independent risk factors of elevated SUA and determine the corresponding cut-off values. Results Compared with those with a normal SUA level, patients with elevated SUA had higher body mass index (BMI), waist-to-hip ratio, F-CP, postprandial 2hC peptide (2hP-CP), triglyceride (TG), homocysteine (HCY), serum creatinine (SCr) level (P<0.05), and a greater percentage of drinking (44.8% vs 32.6%, P=0.006), but had significantly lowered levels of HbA1c, high-density lipoprotein (HDL), and estimated glomerular filtration rate (eGFR) (P<0.05). SUA was found to be positively correlated with F-CP, 2hP-CP, BMI, waist-to-hip ratio, diastolic blood pressure, TG, HCY, SCr, smoking and drinking (P<0.05), and was negatively correlated with gender, age, age of disease onset, HbA1c, HDL and eGFR (P<0.05). SUA level and the incidence of hyperuricemia increasea significantly with F-CP level (P<0.05). F-CP was identified as an independent risk factor for elevated SUA, and gender did not affect the relationship between F-CP and SUA. ROC curve analysis showed that a F-CP level >1.260 ng/mL was associated with a significantly increased risk of hyperuricemia in T2DM patients. Conclusion F-CP is closely related with SUA and may be an independent risk factor of elevated SUA in patients with T2DM.

相似文献/References:

[1]付文金,郑磊,王前,等.2 型糖尿病患者尿液组织因子及其促凝血活性检测的意义[J].南方医科大学学报,2011,(05):878.
[2]郭煜,朱波,李晨钟,等.自发性2型糖尿病大鼠血浆低脂联素血症导致胰岛素抵抗[J].南方医科大学学报,2011,(06):1014.
[3]杜宏,邵加庆,顾萍,等.早期大黄酸干预对db/db小鼠胰岛功能的影响[J].南方医科大学学报,2011,(09):1526.
[4]谭凤明,程喜平,陈盛强,等.不同年龄Ⅱ型糖尿病患者中黑白头发mtDNA异质性研究[J].南方医科大学学报,2012,(01):85.
[5]张定康,俞守义,耿仁文,等.国内应用胰岛素泵治疗2型糖尿病疗效循证研究[J].南方医科大学学报,2006,(08):1211.
[6]贾贺堂,张素华,纪立农,等.北京市100个早发糖尿病家系MODY1基因突变的筛查[J].南方医科大学学报,2006,(09):1301.
 JIA He-tang,ZHANG Su-hua,JI Li-nong,et al.Molecular scanning of MODY1 gene mutations in pedigrees of early onset type 2 diabetes in Beijing[J].,2006,(04):1301.
[7]薛耀明,罗仁,朱波,等.六味地黄丸对自发性2型糖尿病大鼠内脏脂肪分布的影响[J].南方医科大学学报,2006,(10):1446.
 XUE Yao-ming,LUO Ren,ZHU Bo,et al.Liuweidihuang pills reduces visceral fat deposition in Otsuka Long-Evans Tokushima Fatty rats[J].,2006,(04):1446.
[8]许小津,惠宏襄,蔡徳鸿.2型糖尿病患者与健康个体间肠道双歧杆菌的差异[J].南方医科大学学报,2012,(04):531.
[9]徐静,李楠,王俊红,等.2型糖尿病合并非酒精性脂肪肝大鼠肝脏SIRT1、UCP2 表达的变化[J].南方医科大学学报,2012,(05):726.
[10]李卫平,黎文,杨桃.同型半胱氨酸血症与2型糖尿病慢性并发症的关系[J].南方医科大学学报,2005,(03):349.
 LI Wei-ping,LI Wen,YANG Tao.Relationship between plasma homocysteine and chronic complications in type 2 diabetes mellitus[J].,2005,(04):349.

更新日期/Last Update: 1900-01-01